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Ketamine activates HCN1. 5 / 5
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"In addition, normal HCN1-/- and HCN1 +/+ mice were intraperitoneally injected of BrdU and then treated with 5 mg/kg ketamine (KET group, n = 5) or same volume of normal saline (NS group, n = 5) by single intraperitoneal injection."
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"We validated this action of ketamine on an HCN1 mediated native neuronal hyperpolarization activated cationic current (I h) by showing that ketamine mediated inhibition of neuronal I h was absent in HCN1 -/- mice."
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"The mechanism by which ketamine modulates HCN1 channels remains to be determined."
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"Ketamine causes HCN1 dependent membrane hyperpolarization and synaptic enhancement."
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"Correspondingly, ketamine caused membrane hyperpolarization and increased input resistance (R N) in cortical pyramidal cells from wild type but not HCN1 knockout mice (XREF_FIG)."
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