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Ketamine activates HCN1. 7 / 7
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"The mechanism by which ketamine modulates HCN1 channels remains to be determined."
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"For example, the concentrations of ketamine used for anaesthesia also modulate HCN1 channels (Chen et al. 2009)."
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"In aggregate, these results firmly establish a role for ketamine mediated-inhibition of HCN1 channels in both the retrosplenial slow-wave rhythm and the accompanying behavioral dissociation.In humans, the retrosplenial cortex is one region within the posterior cingulate cortex, which in turn is part of the posteromedial cortex (PMC), and the PMC is thought to be a homologous structure to the rodent retrosplenial cortex (129)."
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"Ketamine causes HCN1 dependent membrane hyperpolarization and synaptic enhancement."
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"We validated this action of ketamine on an HCN1 mediated native neuronal hyperpolarization activated cationic current (I h) by showing that ketamine mediated inhibition of neuronal I h was absent in HCN1 -/- mice."
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"Correspondingly, ketamine caused membrane hyperpolarization and increased input resistance (R N) in cortical pyramidal cells from wild type but not HCN1 knockout mice (XREF_FIG)."
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"In addition, normal HCN1-/- and HCN1 +/+ mice were intraperitoneally injected of BrdU and then treated with 5 mg/kg ketamine (KET group, n = 5) or same volume of normal saline (NS group, n = 5) by single intraperitoneal injection."
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