IndraLab

Statements

USP22 increases the amount of MSH3. 3 / 3
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"Subsequently, using qPCR array analysis, we found that knockdown of USP22 could drastically inhibit the expression of MRP1, but not P-gp, in BEL/FU cells."
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"Collectively, USP22 might deubiquitinate SIRT1 and subsequently activate the AKT pathway, increasing the expression of MRP1 to induce MDR in HCC cells."
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"LY294002 (10mum) also suppressed USP22 induced high expression of MRP1 via inhibition of AKT pathway in BEL7402 cells."
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