IndraLab

Statements

Perhexiline inhibits KCNH2. 4 / 4
1 | 2 1
drugbank
No evidence text available
18701618
reach
"Perhexiline caused voltage- and frequency dependent block of HERG (IC50 7.8 microM)."
10369479
reach
"Also worth noting is the exclusion from Pred-hERG AD of 11 hERG blockers including namely clarithromycin, digoxin, epinastine, erythromycin, furosemide, fluvoxamine, mexiletine, perhexiline, procainam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37468081
sparser
"In conclusion, perhexiline potently inhibits transfected HERG channels and this is the probable mechanism for QT prolongation and torsades de pointes."
10369479