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Perhexiline inhibits KCNH2. 3 / 4
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"Perhexiline caused voltage- and frequency dependent block of HERG (IC50 7.8 microM)."
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"In conclusion, perhexiline potently inhibits transfected HERG channels and this is the probable mechanism for QT prolongation and torsades de pointes."
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"Also worth noting is the exclusion from Pred-hERG AD of 11 hERG blockers including namely clarithromycin, digoxin, epinastine, erythromycin, furosemide, fluvoxamine, mexiletine, perhexiline, procainam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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