IndraLab

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Ube4b activates ATXN3. 1 / 1

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"We found that E4B targets the pathological form of ataxin-3 -- in which abnormal expansion of a polyglutamine tract is responsible for spinocerebellar ataxia type 3 (SCA3) in humans -- for ubiquitylation and degradation in mammalian cells as well as in a Drosophila melanogaster model of SCA3 [XREF_BIBR]."

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INDRA sources:

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IndraLab

Statements

Ube4b activates ATXN3. 1 / 1

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