IndraLab

Statements

PSMD14 activates HDAC6. 4 / 6
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reach
"We conclude that proteasome associated Poh1 activates HDAC6 dependent actinomyosin machinery to facilitate the de-aggregation and clearance of the aggresome."
24035499
sparser
"These results support the model wherein Poh1 activates HDAC6- and cortactin-dependent F-actin remodeling required for aggresome clearance."
24035499
reach
"These results support the model wherein Poh1 activates HDAC6- and cortactin dependent F-actin remodeling required for aggresome clearance."
24035499
sparser
"Based on aggresome clearance assays and immunoprecipitation experiments in cultured HEK-293T cells, unanchored Lys63-linked Ub chains created by en bloc cleavage by the proteasomal DUB, POH1 bind to and activate HDAC6, promoting clearance of aggresomes ( xref )."
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