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P5091 activates CCDC6. 1 / 1
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"Notably, by adding back ectopic wt CCDC6 plasmid to the LNCaP treated with P5091, we were able to rescue the weak sensitivity to olaparib, in terms of 50% inhibitor concentration values (IC50) (XREF_SUPPLEMENTARY), suggesting a pivotal role of CCDC6 as a USP7 substrate."