IndraLab

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TWIST1 inhibits USP13. 4 / 4
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"We found that the effect of USP13 in promoting the migration and invasion capacities of breast cancer cells can at least partly be achieved through its regulation of Twist1, while Twist1 can inhibit the transcriptional activity of USP13."
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"However, this finding is contradictory to the notion that Twist1 inhibits USP13 promoter activation."
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"In addition, we found that Twist1 could inhibit the activity of the USP13 promoter in a dose-dependent manner (Fig. 7c), and directly bind to the USP13 promoter in SUM159PT cells as demonstrated by ChIP (Fig. 7d)."
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"A possible, but one-sided explanation may be that normal physiological concentrations of Twist1 individually inhibit USP13 promoter activation, whereas abnormal expression of USP13 may induce Twist1 to recruit co-factors to promote the transcription of its target genes including USP13."
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