IndraLab

Statements

UCHL1 activates translation. 27 / 27
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"Antisense Uchl1 RNA promotes association of Uchl1 mRNA with active polysomes and enhances protein translation."
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"In a similar case, this new mechanism was also proposed by one previous work which reported that the uchl1 gene lncRNA enhances the translation of its target mRNA via base pairing and by recruiting additional ribosomes via the functional element."
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"An antisense transcript of UCHL1, UCHL1-AS promotes translation of UCHL1 169, which is strongly attenuated in neurochemical models of PD in vitro and in vivo 169."
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"In that sense, UCHL1-AS targets Uchl1 mRNA to induce its translation and increasing UCHL1 levels [XREF_BIBR]."
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"TINCR is induced during epidermal differentiation and is required for stability of differentiation mediators and antisense Uchl1 lncRNA promotes translation of Uchl1 in mouse."
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"UCH-L1 could stimulate mRNA translation by associating with and enhancing assembly of the translation initiation complex."
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"Upon increasing the binding of UCHL1 mRNA to the polymer, antisense lncRNA UCHL1 enhances the UCHL1 mRNA translation."
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"AS Uchl1 promotes Uchl1 mRNA translation by facilitating assembly of the translation initiation complex (Carrieri et al., 2012)."
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"Under stress conditions where cap dependent translation is inhibited, antisense Uchl1 IncRNA, previously enriched in the nucleus, moves into the cytoplasm and hybridizes with Uchl1 mRNA to enable cap independent translation of Uchl1."
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"AS-Uchl1 induces Uchl1 expression by promoting Nurr1 translation."
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"Very recently, it has been reported that antisense (AS) Uchl1 (ubiquitin carboxyterminal hydrolase L1), a nuclear enriched lncRNA complementary to the mRNA that encodes Uchl1, an enzyme with roles in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further study reveals that antisense Uchl1 exports from the nucleus to the cytoplasm and interacts with Uchl1 mRNA when treated with rapamycin, which helps to recruit ribosomes to Uchl1 mRNA hence pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, the embedded invSINEB2 element of the lncRNA AS Uchl1 regulates AS Uchl1 nuclear retention and consequently inhibits AS Uchl1-enhanced translation of the sense protein-coding Uchl1 mRNA by recruiting IL enhancer-binding factor 3 (ILF3) [46]."
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"Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment."
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"It is predominantly nuclear, but it can shuttle to the cytoplasm under stress conditions to bind to the 5′UTR of Uchl1 mRNA, thus triggering increased translation of the UCHL1 protein [60] (Figure 3a)."
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"This technology originates from its natural prototype RNA transcript, the uchl1 gene lncRNA, which Carrieriet al. found to enhance the translation of its corresponding sense mRNA via base pairing and by recruiting multiple ribosomes via the functional element SINEB2."
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"AS Uchl1 enhances translation of UCHL1 (ubiquitin carboxy-terminal hydrolase L1) through an embedded SINE (short interspersed nuclear element) B2 repeat present in AS Uchl1 [XREF_BIBR]."
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"Exact molecular mechanism as to how AS Uchl1 promotes the translation of Uchl1 mRNA under stress conditions is still elusive."
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"In addition, another lncRNA antisense Uchl1, which activates uchl1 translation through the embedded SINEB2 repeat, also enhances the association of Uchl1 mRNA to active polysomes xref ."
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"The CRISPR/dCasRx-SINEB2 technology was developed in this research by coupling the sgRNA of a catalytically inactive Type VI-D Cas13 enzyme (CasRx) to an integrated SINEB2 domain of uchl1 lncRNA that promotes the translation of targeted mRNA."
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"A neuron specific antisense lncRNA, AS Uchl1, could specifically induce the translation of ubiquitin carboxyl-terminal esterase L1 (Uchl1) under certain stress conditions through its complementarity with target mRNA [XREF_BIBR]."
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"Under conditions of cellular stress, AS Uchl1 shuttles to the cytoplasm, where it induces Uchl1 mRNA to become highly loaded with ribosomes, thereby increasing its translation [XREF_BIBR]."
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"In addition, another lncRNA antisense Uchl1, which activates uchl1 translation through the embedded SINEB2 repeat, also enhances the association of Uchl1 mRNA to active polysomes XREF_BIBR."
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"The antisense strand of UCHL1 (UCHL1-AS) is responsible for the post-transcriptional and translational processing of UCHL1, increasing the protein synthesis of UCHL1."
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", AS Uchl1 stimulates translation of partially overlapping sense protein coding mRNAs with no effects on RNA levels."
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"The AS Uchl1 lncRNA interacts with Uchl1 mRNA to enhance its translation, while lincRNA-p21 represses the translation of JUNB and CTNNB mRNAs."
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"The mature lncRNA contains a 73-nucleotide complementary site with the 5 ' end of the Uchl1 mRNA, which serves to upregulate translation of Uchl1 mRNA [XREF_BIBR]."
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