IndraLab

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OTUD4 decreases the amount of SERPINE1. 2 / 2
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"Reduced OTUD4 inhibited the expression of PAI-1 protein (Fig. 6A, left panel), while overexpression of OTUD4 partially reversed the protein level of PAI-1 in CSE treated BEAS-2b cells (Fig. 6A, right panel)."
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"In addition, ubiquitination assay showed that CSE can increase ubiquitination and degradation of PAI-1, while enhanced OTUD4 expression can decrease the ubiquitination level of PAI-1 induced by CSE (Fig. 7E)."
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