IndraLab

Statements

USP18 activates PTEN. 3 / 3
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"ISGylation reduces the cytoplasmic content of PTEN, while USP18-mediated deISGylation promotes PTEN protein stability and recovery of its cytoplasmic expression (Mustachio et al., 2017)."
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"Interestingly, repression of USP18 decreased cytoplasmic PTEN relative to nuclear PTEN protein levels."
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"However, USP18 overexpression could stabilize PTEN protein, and USP18 repression decreases mainly cytoplasmic PTEN [XREF_BIBR]."
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