IndraLab

Statements

reach
"These results indicate that the N-terminal domain of p6 may play a role in the formation of the replication complex in SARS-CoV-infected cells and serve auxiliary or modulatory functions during SARS-C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24995382
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"While p-STAT1 was considerably increased in both cell lines in the presence of cisplatin, P6 almost entirely suppressed p-STAT1 in both cell lines."
21945668
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"XREF_BIBR P6 suppressed the IFN-gamma and STAT1, IL-2 and STAT5, and IL-4 and STAT6 signaling pathways strongly while it suppressed IL-6 and STAT3 pathway only modestly, resulting in reduction of the Th1 and Th2 responses but the enhancement of the T17 response."
24069552
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"We also demonstrated that BMDMs from STAT1 -/- mice and BMDMs from WT mice treated with JAK-I inhibitor failed to induce the expression of Dll1 following stimulation with PolyI : C, H1N1 or rIFN-beta (XREF_FIG E and F)."
22072963
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"Protein 6 was identified as a beta-interferon antagonist by Kopecky-Bromberg et al. with the intriguing finding that overexpression of p6 inhibits nuclear import of STAT1 in cells treated with IFN-beta."
24995382