IndraLab

Statements

USP7 inhibits cell growth. 14 / 15
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"HAUSP also induced p53-dependent cell growth repression and apoptosis."
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"Tumor cell growth, volume, and weight were decreased by the depletion or inhibition of HAUSP XREF_BIBR XREF_BIBR."
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"As the s, P5091 is also an elective dual-inhibitor of USP7 and USP47 that can suppress CRC cell growth and induces their apoptosis in vitro (An et al., 2017)."
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"Thus, HAUSP appears to play multiple roles in regulating the p53-MDM2 pathway as well as in EBV induced tumor cell survival, and is hence a potential chemotherapeutic target for p53 mediated suppression of tumor cell growth."
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"In fact, total knock-out of USP7 also blocks cell growth in T-ALL cells, emphasizing the dosage-dependence of heterozygous USP7 LOF mutations in pediatric T-ALL."
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"A study has shown that USP7 deubiquitinates and stabilizes E3 ubiquitin ligase MDM2, and thereby promotes MDM2-mediated ubiquitinated degradation of p53 and cell growth in ovarian cancer cells."
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"Also, USP7 overexpression suppresses LUAD cell growth through inhibition of the ERK1/2 signaling pathway independently of p53."
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"In T-ALL, USP7 forms a co-regulatory complex with HEB, TAL1 and E2A then inhibiting T-ALL cell growth [55]."
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"In Multiple Myeloma (MM), where patients with activated NFKB signaling though NEK2 have poorer outcomes, USP7 inhibitors effectively inhibit myeloma cell growth and overcome NEK2-induced and NEK2- acquired drug resistance in xenograft models [ xref ]."
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"Targeting USP7 further suppresses cellular growth and sensitizes USP22-Ko lung cancer cells to cisplatin treatment."
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"Furthermore, we found that the upregulation of TBX3 reversed the increased expression of p57 KIP2 and the repressed cell growth induced by USP7 downregulation ( Fig. 5 d-f)."
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"Downregulation of USP7 reduces HCC cell growth and metastasis and is responsible for drug sensitivity [149]."
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"P22077, a representative small-molecule inhibitor of USP7, has been validated for its ability to induce MYCN protein degradation and inhibit NB cell growth (31)."
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"We showed that APC truncations lacking the CID make β-catenin vulnerable to USP7 deubiquitination: depletion of USP7 in APC-mutant CRC cell lines and mouse organoids inhibits WNT and suppresses cell growth."
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