IndraLab

Statements

USP7 inhibits cell growth. 4 / 5
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"Thus, HAUSP appears to play multiple roles in regulating the p53-MDM2 pathway as well as in EBV induced tumor cell survival, and is hence a potential chemotherapeutic target for p53 mediated suppression of tumor cell growth."
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"Tumor cell growth, volume, and weight were decreased by the depletion or inhibition of HAUSP XREF_BIBR XREF_BIBR."
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"In fact, total knock-out of USP7 also blocks cell growth in T-ALL cells, emphasizing the dosage-dependence of heterozygous USP7 LOF mutations in pediatric T-ALL."
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"In Multiple Myeloma (MM), where patients with activated NFKB signaling though NEK2 have poorer outcomes, USP7 inhibitors effectively inhibit myeloma cell growth and overcome NEK2-induced and NEK2- acquired drug resistance in xenograft models [ xref ]."
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