IndraLab

Statements

USP2 deubiquitinates MDM2. 4 / 4
1 | 3
reach
"USP2 deubiquitinates both MDM2 and MDMX [XREF_BIBR, XREF_BIBR] whereas USP4 deubiquitinates ARF-BP1 [XREF_BIBR], another ubiquitin ligase for p53, thus indirectly destabilizing p53 and inhibiting its function."
28035068
reach
"Specifically, protein-protein interaction assays using the bacterial two-hybrid system showed that USP2 can deubiquitinate MDM2 and promotes p53 degradation, showing the association between USP2 and MDM2 (Stevenson et al., 2007)."
34539442
reach
"USP2 deubiquitinates and stabilizes MDM2 thus inhibiting the proapoptotic activity of p53."
29479529
ubibrowser
"Review"
28801249