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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP2 deubiquitinates MDM2. 4 / 4

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"USP2 deubiquitinates both MDM2 and MDMX [XREF_BIBR, XREF_BIBR] whereas USP4 deubiquitinates ARF-BP1 [XREF_BIBR], another ubiquitin ligase for p53, thus indirectly destabilizing p53 and inhibiting its function."

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"Specifically, protein-protein interaction assays using the bacterial two-hybrid system showed that USP2 can deubiquitinate MDM2 and promotes p53 degradation, showing the association between USP2 and MDM2 (Stevenson et al., 2007)."

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"USP2 deubiquitinates and stabilizes MDM2 thus inhibiting the proapoptotic activity of p53."

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USP2 deubiquitinates MDM2. 4 / 4

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