IndraLab

Statements

USP2 deubiquitinates MDM2. 5 / 6
1 | 5
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"USP2 deubiquitinates both MDM2 and MDMX [XREF_BIBR, XREF_BIBR] whereas USP4 deubiquitinates ARF-BP1 [XREF_BIBR], another ubiquitin ligase for p53, thus indirectly destabilizing p53 and inhibiting its function."
28035068
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"MDM2 can also be deubiquitinated by USP2, and this may contribute to osteosarcoma tumorigenesis [85]."
38534381
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"Specifically, protein-protein interaction assays using the bacterial two-hybrid system showed that USP2 can deubiquitinate MDM2 and promotes p53 degradation, showing the association between USP2 and MDM2 (Stevenson et al., 2007)."
34539442
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"USP2 deubiquitinates and stabilizes MDM2 thus inhibiting the proapoptotic activity of p53."
29479529
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"USP2 deubiquitinates the E3 ligase MDM2 and prevents its degradation [23] , and thus, we explored the effects of UbVs on MDM2 ubiquitination."
30763569