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Modified BAP1 decreases the amount of SLC7A11. 2 / 2
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"We confirmed that re-expression of BAP1 WT, but not its C91A mutant, in UMRC6 cells decreased SLC7A11 expression (XREF_FIG), suggesting that BAP1 mediated repression of SLC7A11 expression requires BAP1 's DUB activity."
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"Similarly, BAP1 re-expression in NCI-H226 cells, a BAP1 deficient mesothelioma cell line with high SLC7A11 expression (see XREF_FIG), also repressed SLC7A11 expression (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
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