IndraLab

Statements

NKX2-5 inhibits HCN4. 4 / 5
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eidos
"NKX2.5 , a main transcriptional factor of working myocardium , upregulates the expression of downstream genes including SCN5A but represses the expression of HCN4 ( Barbuti and Robinson , 2015 ; Vedantham , 2015 ) ."
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"In working atrial myocardium that lacks the repressive effects of Shox2, Nkx2.5 activates expression of chamber specific genes (Cx40/Cx43/ANF) and represses SAN specific genes (Tbx3 and HCN4) to prevent ectopic pacemaker formation."
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"Nkx2-5 acts to repress Hcn4 and Tbx3, and is required to establish the SAN-atrial boundary [XREF_BIBR, XREF_BIBR]."
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"SHOX2 inhibits NKX2.5 expression and activates a pacemaker genetic pathway that results in up-regulation of the GATA6 and TBX3 transcription factors, and HCN4 channel."
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