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"Human VSMCs were transfected with a control or AIP1 siRNA followed by treatment with human IFN-gamma in the absence or presence of a specific inhibitor to JAK2 (AG490), STAT1 (Fludarabine, a purine analog that has been shown to specifically inhibit STAT1 in VSMC) 38 or STAT3 (Stattic, a nonpeptide small molecule inhibitor of STAT3 activation and dimerization) 39."