IndraLab

Statements

ADAM17 binds TNFRSF1A. 4 / 4
1 | 2 1
reach
"The TNF-alpha-converting enzyme TACE can cleave membrane bound TNFR1 and TNFR2 to yield soluble TNF receptors, which have higher affinity for TNF-alpha."
28102063
sparser
"Activation of the ADAM17-TNFR1 signaling module using small-molecule protein disulfide isomerase (PDI) inhibitors effectively induces TNFR1 shedding and TNF-α signaling inhibition."
41318528
biogrid
No evidence text available
17010968
reach
"Julia and colleagues suggested that TNFR1-dependent tumor cell-induced endothelial cell death, tumor cell extravasation, TNF-induced necroptosis, and subsequent metastatic seeding rely on the activation of the membrane-bound metalloprotease ADAM17."
38613350