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Mice activates OTUD4. 2 / 2
| 2

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"Our data indicate that knockout of OTUD4 in mice greatly impairs the replication of MHV68, a murine herpesvirus closely related to KSHV, thereby validating the critical role of OTUD4 in MHV68 replication in vivo."

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"Compared with that in the IR and IR + NC groups of mice, the inflammatory cell infiltration was ameliorated in mice overexpressing OTUD4 ( Fig. 4 C and D)."