IndraLab

Statements

USP18 activates MAP3K7. 6 / 6
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"However, NEMO deficiency did not lead to loss of interaction between USP18 and TAK1 (XREF_FIG), suggesting that USP18 targets TAK1 complex and IKK complex by distinct mechanisms."
26240016
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"Based on our experimental data, we propose a working model to explain how USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO."
26240016
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"USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms."
26240016
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"Recent work has demonstrated that USP18 has the ability to deubiquitinate the transforming growth factor-activated kinase 1 (TAK1) complexes required for NF-κB activation in T cells and that overexpression of USP18 leads to decreased nuclear activation and impaired formation of TAK1 complexes (47)."
27009955
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"After TLR ligand stimulation, TAK1 and NEMO undergo K63 linked ubiquitination by TRAF6, while upregulated USP18 targets TAK1 and NEMO."
26240016
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"Considering the phenotypes observed with Tak -/- and Usp18 -/- T cells or Usp18 -/- T cells transfected with USP18 (WT) or USP18 (C61S), we further hypothesized that USP18 targets TAK1 complex and catalyzes deubiquitination of TAK1."
23825189