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MAPK activates KCNA3. 16 / 16
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"Using this assay, we quantitatively evaluate the role of the MAPK-activated protein kinases MK2 and MK3 in fibroblast migration."
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"MAPK-activated kinases MK2 and MK3 are uniquely activated by p38 MAPK, whereas the mitogen- and stress-activated kinases MSK1 and MSK2 can be activated by either p38 MAPK or ERK."
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"The following sections consider other protein kinases of the innate immune system with the potential to be superior drug targets to p38α MAPK.MAPKAP-K2 (MK2) and the closely related MK3 isoform are ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This applies to the MAPK-activated protein kinases MK2 and MK3."
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"The MAPK-activated protein kinases MK2 and MK3, function as sensors of cell injury and exert pivotal roles in IL-33-induced cytokine production by mast cells in inflammatory responses ( xref , xref , xref )."
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"Besides, MAPK-activated protein kinases 2 (MK2) and MK3 can be activated by p38, and mediate the activation of phosphoinositide 3-kinase (PI3K) p110δ [47–49] ."
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"Those functionally subordinate to p38 include MAPK-activated protein kinases MK2 and MK3 (also called MAPKAP-K2 and MAPKAP-K3), mitogen- and stress-activated kinases MSK1 and MSK2, and MAPK-interacting kinases MNK1 and MNK2."
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"p38 MAPK, through the intermediates MAPK-activated kinase 2 (MK2) and MK3, can activate p90RSK in certain situations, such as viral infection [30,31]."
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"Inhibitors of p38α MAPK may therefore suppress the beneficial anti-inflammatory effects of MSK1/MSK2 as well as the pro-inflammatory effects of MK2/MK3."
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"This is partially regulated by p38 mitogen-activated protein kinase (MAPK), which further activates two closely related isoforms of the MAPKactivated protein kinases (MKs), MK2 and MK3."
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"Therefore, it can be suggested that MK2 and MK3 altogether affects 311 CHIKV progeny release without affecting viral protein synthesis.The MAPK-activated protein kinases MAPKAPK3 (MK3) and MAPKAPK2 (MK2) In order to confirm the involvement of actin fibers in CHIKV progeny release, Vero cells were 373 virus infected and drug treated as mentioned above and cells were fixed at 18 hpi."
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"Based on structural and functional homology, the MAPKAPKs are divided in four subfamilies: ribosomal S6 kinase (RSK) with the members RSK1-4; mitogen- and stress-activated kinase (MSK) comprising MSK1 and MSK2; MAPK-interacting protein kinase (MNK) including MNK1 and MNK2, and the MAPK-activated protein kinases (MAPKAPK) MK2, MK3 and MK5 [ xref - xref ]."
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"The closely-related mitogen-activated protein kinase-activated protein kinases MK2 and MK3 are involved in both up- and down-regulation of inflammation in mammals and govern the inflammatory response at different regulatory levels of gene expression and with different kinetics."
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"We demonstrate that the mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) MK2 and MK3 are activated on virus infection and, in their active form, directly interact with the repressor of the inhibitor of PKR p88(rIPK)."
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"MAPKAPK5/PRAK is a serine/threonine kinase was originally identified based on homology with two other MAP kinase activated kinases, MK2 and MK3 [ xref , xref ]."
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"MK2/MK3 is activated during amino acid starvation by the well-characterized upstream MAPK, p38α (Trempolec et al., 2013)."
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