IndraLab

Statements

Imiquimod inhibits TLR7. 6 / 6
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"Reduced cell infiltration was observed in the bladder of TLR7 deficient mice treated with R-837 in poloxamer-HPbetaCD formulation similar to saline treated mice, indicating that inflammation induced by R-837 in the bladder was TLR7 dependent (XREF_FIG)."
20337728
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"Imiquimod mediated TLR7 activation induces secretion of proinflammatory cytokines, suppresses Tregs, and induces Th1 cell mediated activation of NK cells to eradicate cancer cells [XREF_BIBR]."
28116316
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"Soluble Imiquimod Directly Inhibits the Growth of TLR7 - GL261 Glioma Cells."
21389872
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"Conversely, 100 nM TLR7 ligand significantly induced cell proliferation (XREF_FIG); however, the induction of proliferation was blocked by the addition of 100 microM Imiquimod, indicating that 100 microM Imiquimod effectively reversed the oncogenic function of the TLR7 ligand following 48 h of incubation (XREF_FIG)."
27123047
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"If the induction of XPA gene expression is dependent on classical TLR signaling, we hypothesized that Bayer compound would block the up-regulation of XPA gene expression after TLR7 stimulation by imiquimod."
21765012
eidos
"Allopregnanolone completely inhibited TLR7 activation by imiquimod , blocking IL-1-beta , IL-6 , pSTAT1 and pIRF7 elevations in females only ."
35967446