IndraLab

Statements

Imiquimod inhibits TLR7. 11 / 11
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"Conversely, 100 nM TLR7 ligand significantly induced cell proliferation (XREF_FIG); however, the induction of proliferation was blocked by the addition of 100 microM Imiquimod, indicating that 100 microM Imiquimod effectively reversed the oncogenic function of the TLR7 ligand following 48 h of incubation (XREF_FIG)."
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"However, in a later study, we have found that imiquimod also induces intracellular Ca 2+ signaling and action potentials in TLR7-deficient mouse sensory neurons [7] ."
24971541
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"Reduced cell infiltration was observed in the bladder of TLR7 deficient mice treated with R-837 in poloxamer-HPbetaCD formulation similar to saline treated mice, indicating that inflammation induced by R-837 in the bladder was TLR7 dependent (XREF_FIG)."
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"If the induction of XPA gene expression is dependent on classical TLR signaling, we hypothesized that Bayer compound would block the up-regulation of XPA gene expression after TLR7 stimulation by imiquimod."
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"Soluble Imiquimod Directly Inhibits the Growth of TLR7 - GL261 Glioma Cells."
21389872
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"Finally, imiquimod inhibits hedgehog signaling, which drives basal cell carcinoma malignancy, in a TLR7-independent manner via PKA."
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"To examine whether allopregnanolone as well as 3α,5α-THDOC and SGE-516 also inhibit activation of TLR7 signal and pathway members in hMDM, cells were treated with the TLR7 agonist imiquimod (IMQ) (30 µg/ml; 24 hrs) in the absence or presence of allopregnanolone (1.0 µM), 3α,5α-THDOC (1.0 µM) or SGE-516 (1.0 µM)."
35967446
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"However, we found that imiquimod triggers Ca 2+ signaling in TLR7-deficient DRG sensory neurons [7] ."
24971541
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"However, the approval of imiquimod is limited to localized administration only (9), necessitating the development of systemically available TLR7 agonists to tackle tumors that are not superficially located (10)."
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"Allopregnanolone completely inhibited TLR7 activation by imiquimod , blocking IL-1-beta , IL-6 , pSTAT1 and pIRF7 elevations in females only ."
35967446
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"Imiquimod mediated TLR7 activation induces secretion of proinflammatory cytokines, suppresses Tregs, and induces Th1 cell mediated activation of NK cells to eradicate cancer cells [XREF_BIBR]."
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