IndraLab

Statements

KCNH2 binds betA1. 3 / 3
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"The scDb-hERG1-beta1 (1) downregulates the formation of the hERG1 and beta1 complex, (2) inhibits Akt phosphorylation and HIF-1alpha expression and (3) decreases cell survival, proliferation and migration in vitro."
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"We provide evidence that the scDb we produced binds to the hERG1 and beta1 complex in cancer cells and tissues, whereas does not bind to the hERG1 channel in non pathological tissues, in particular the heart."
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"Hence, both an activated integrin and a functional channel are required for the hERG1 and beta 1 complex formation (see the cartoon bottom right in XREF_FIG)."
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