IndraLab

Statements

USP13 inhibits mutated EGFR. 3 / 3
| 3
reach
"23 In HEK293T cells expressing EGFR-DeltaE740-A746, USP13 antagonized the destabilization of mutant EGFR mediated by c-Cbl or Cbl-b."
33210294
reach
"We demonstrate that USP13 targeting leads to an increased sensitivity toward EGFR inhibition by both osimertinib and afatinib in NSCLC harboring the most common EGFR mutations (DeltaE746-A750 and L858R and T790M) while sparing EGFR wild-type cells and tumors."
33210294
reach
"Overall, we showed that USP13 abrogates sorting and degradation of ubiquitinated mutant EGFR, independent of its catalytic activity but requiring its UBA domains that are known to bind to K63-type ubiquitin chains preferentially."
33210294