IndraLab

Statements

OTUD3 activates HSPA5. 11 / 11
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"The result was consistent with the downregulation of GRP78 by OTUD3 knockdown in the H1299 cell line [26]."
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"OTUD3 upregulates GRP78 in a manner dependent on its deubiquitinating activity, as the catalytically inactive mutant C76A lost its ability to upregulate GRP78 [26]."
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"The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer."
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"OTUD3 positively regulates GRP78, which in turn promotes the growth of LUAD cells68."
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"OTUD3 promotes lung tumorigenesis by stabilizing GRP78 [44], while it stabilizes ACTN4 to drive hepatocellular carcinoma progression and metastasis [45]."
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"Our previous study indicated that deubiquitinase OTUD3 promoted the progression of lung cancer through stabilizing GRP78 [2]."
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"As OTUD3 binds to and positively regulate GRP78 protein stability , we hypothesized that OTUD3 might increase GRP78 expression via deubiquitylation of GRP78 ."
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"Our previous study confirmed that OTUD3 promotes lung tumorigenesis by stabilizing the substrate GRP78 [2]."
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"The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer."
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"In contrast to the downregulation of GRP78 stability and the suppression of tumor metastasis by GP78, OTUD3 enhances GRP78 stability, leading to the growth of lung cancer cells and contributing to tumorigenesis [54, 55]."
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"A previous study demonstrated that OTUD3 promotes lung tumorigenesis by stabilizing GRP78 [26]."
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