IndraLab

Statements

USP2 inhibits TGFB. 6 / 6
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"USP2 depletion induced TGF-β signaling and progression of GBM."
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"Conversely, USP2 inhibits glioblastoma development by suppressing the TGF-B signaling pathway through the deubiquitination of SMAD7 [19]."
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"In contrast, we found that USP2 inhibits the TGF-β signaling and the proliferation of myeloid cells."
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"Whether USP2 down-regulates TGF-β pathway dependently on SMAD7 in myeloid cells in such a context as DSS treatment requires further investigation."
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"Collectively, these data suggest that USP2 negatively regulates TGF-β signaling to suppress myeloid cells proliferation in the lamina propria during DSS-induced colitis, although it promotes TGF-β signaling and exhibits cytostatic effects in multiple non-immune cells.One major function of myeloid cells is to activate T cells during infection and inflammation."
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"More recently, it was published that loss in USP2 expression due to DNMR3A-mediated aberrant DNA methylation enhances TGF-β signaling and GBM progression."
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