IndraLab

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THBS1 binds SDC4. 26 / 26
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"The results revealed that many unique pathways are enriched in the communications involving the KYNU(+) macrophage subpopulation, such as THBS (THBS1-CD47, THBS1-SDC1, THBS1-SDC4), TENASCIN (TNXB-SDC4), THY1 (THY1-(ITGAX+ITGB2)), GALECTIN (LGALS9-HAVCR2), ICAM (ICAM1-(ITGAX+ITGB2)), ANNEXIN (ANXA1-FPR1), and COMPLEMENT (C3-(ITGAX+ITGB2))."
37954130
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"Outeiro-Bernstein et al. discovered that the binding of THBS1 to SDC4 inhibited the apoptosis of vascular endothelial cells and maintained their adhesion function [ xref ]."
37954130
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"Ferrari do Outeiro-Bernstein et al. discovered that the binding of THBS1 to SDC4 inhibited apoptosis of vascular endothelial cells and maintained their adhesion function [70]."
37905960
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"Endothelial cells demonstrated profibrotic signaling via THBS1-SDC4, PDGFB-PDGFRα, and JAG1-NOTCH3 signaling targeting epithelial cells, fibroblasts, and smooth muscle cells, respectively."
41491179
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"Further ligand-receptor analysis revealed that immune signal axis such as Tnf−Tnfrsf1a, Itga4-Vcam1, Thbs1−Sdc4, Cxcl1−Cxcr2 might participate in the intercellular crosstalk between injured PTCs, macrophage, and monocytes ( xref – xref and xref )."
35603220
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"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [XREF_BIBR]."
24171112
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"Outeiro-Bernstein et al. discovered that the binding of THBS1 to SDC4 inhibited the apoptosis of vascular endothelial cells and maintained their adhesion function [51]."
37954130
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"Additional novel L–R gene pairs FGF-NRP1, THBS1-SDC4 , and ANXA2-ROBO4 are non- VEGF L–R pairs, identified within the angiogenic regulation group and previously shown to regulate and maintain the microvasculature within glomeruli ( xref – xref )."
35872784
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"The chord diagram illustrates THBS1-SDC4 signaling among endothelial cells, epithelial cells, fibroblasts, and smooth muscle cells (Fig.  xref A)."
41491179
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"A high degree of interaction between THBS1-SDC4 and CNN1-SDC4 was observed, indicating that fibroblasts are the main sending cells affecting changes in the epithelial cell pathway ( xref )."
39650663
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"In saline mice, we discovered major interactions between Thbs1 (thrombospondin1) and Sdc1 (Syndecan-1), Sdc4 (Syndecan-4), and Cd36 (Figure 7E)."
36516760
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"Analysis of outgoing FN1, THBS, and SPP signaling from Mono&Maph to vascular cells revealed several ligand-receptor pairs with high communication probabilities, including Fn1-Sdc4 and Fn1- (Itga5 + Itgb1), Thbs1-Sdc4, and Spp1- (Itga5 + Itgb1) respectively (Fig.  xref )."
36721040
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"Interaction between thrombospondin 1 (THBS1) and syndecan 4 (SDC4) was predicted to mediate the interaction of basal, neuroendocrine, and tuft cells with UCT cells ( xref )."
40721095
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"Among the ligand-receptor pairs of THBS signaling, the Thbs1-Sdc4 ligand-receptor pair showed the highest communication probability, especially in Maph-2 to SMC-2 communication ( xref )."
35187133
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"Examination of each ligand-receptor pair in THBS signaling revealed that Thbs1-Sdc4 signaling was the dominant pathway from macrophages to SMCs, especially from Maph-1 to SMC-2 ( xref )."
35187133
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"Thbs1-Sdc4 and Thbs1-Cd47 were responsible for communication from SMCs to macrophages, and from Fib-2 to fibroblasts, SMCs, and macrophages ( xref )."
35187133
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"By analyzing each ligand-receptor pair of THBS signaling between macrophages and SMCs, we identified that Thbs1-Sdc4 was the most elevated pathway sent from Maph-2 to SMCs (especially synthetic SMC-2), and that Thbs1-Cd47 signaling sent from SMC-2 to macrophages (especially pro-inflammatory Maph-2) was decreased by AAA."
35187133
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"Of note, Thbs1-Sdc4 signaling was increased the most at Day 7, and slightly decreased at Day 14."
35187133
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"Thbs1-Sdc4 and Thbs1-Cd47 were the major signaling pathways sent from SMCs (SMC-3) to macrophages."
35187133
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"Although UCT cells demonstrated low levels of THBS1 expression, the reciprocal interaction of THBS1 and SDC4 may explain the high interaction probability of this pair within the UCT cells."
40721095
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"However, by binding to syndecan-4, TSP-1 can also exert pro angiogenic effects, protecting ECs from apoptosis and stimulating tubulogenesis [XREF_BIBR]."
27713299
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"Ligand-receptor pairs such as ADGRE5-CD55, CD99-CD99, and THBS1-SDC4 were shown to increase in incoming signaling from monocytes in the non-survivor group in both methods, while HLA-DMB-CD4, ANXA1-FPR2, and FCER2A-(ITGAX+ITGB2) were shown to decrease in incoming signaling from monocytes in the non-surviving sepsis group in both methods."
41124448
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"We performed a clinical relevance analysis on the representative ligand-receptor pairs in the PAAD data from TCGA and found that the ligand-receptor pairs represented by ADGRE5-CD55, AGRN-DAG1, EFNA1-EPHA2, COL1A1-CD44, THBS1-SDC4, and LGALS9-CD44 were expressed at a higher level in tumor tissues compared with normal tissues, and the high expression of ligand-receptor pairs was associated with poor prognosis ( xref B and xref )."
40538442
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"In state 1, neutrophils engaged macrophages predominantly via Thbs1‐Cd36, Thbs1‐Cd47, and Thbs1‐Sdc4 axes, which are closely associated with immune suppression and macrophage polarization (Figure xref , Supporting Information)."
41134086
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"When macrophages acted as signal senders, the THBS (THBS1-CD47, THBS1-SDC1, and THBS1-SDC4) pathway was enriched in the cell interactions of the KYNU(+) macrophage subpopulation."
37954130
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"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [ xref ]."
24171112