IndraLab

Statements

SDC4 binds THBS1. 9 / 9
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"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [XREF_BIBR]."
24171112
sparser
"Thbs1-Sdc4 and Thbs1-Cd47 were the major signaling pathways sent from SMCs (SMC-3) to macrophages."
35187133
sparser
"Examination of each ligand-receptor pair in THBS signaling revealed that Thbs1-Sdc4 signaling was the dominant pathway from macrophages to SMCs, especially from Maph-1 to SMC-2 ( xref )."
35187133
sparser
"There are indications that binding of TSP-1 to syndecan-4 proteoglycan mediates tubulogenesis and their protection from apoptosis [ xref ]."
24171112
reach
"However, by binding to syndecan-4, TSP-1 can also exert pro angiogenic effects, protecting ECs from apoptosis and stimulating tubulogenesis [XREF_BIBR]."
27713299
sparser
"Among the ligand-receptor pairs of THBS signaling, the Thbs1-Sdc4 ligand-receptor pair showed the highest communication probability, especially in Maph-2 to SMC-2 communication ( xref )."
35187133
sparser
"By analyzing each ligand-receptor pair of THBS signaling between macrophages and SMCs, we identified that Thbs1-Sdc4 was the most elevated pathway sent from Maph-2 to SMCs (especially synthetic SMC-2), and that Thbs1-Cd47 signaling sent from SMC-2 to macrophages (especially pro-inflammatory Maph-2) was decreased by AAA."
35187133
sparser
"Of note, Thbs1-Sdc4 signaling was increased the most at Day 7, and slightly decreased at Day 14."
35187133
sparser
"Thbs1-Sdc4 and Thbs1-Cd47 were responsible for communication from SMCs to macrophages, and from Fib-2 to fibroblasts, SMCs, and macrophages ( xref )."
35187133