IndraLab

Statements

OTUB1 activates UBE2N. 5 / 5
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"The deubiquitinase OTUB1 augments NF-kappaB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13."
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"Recent studies also show that OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13 [76]."
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"Mechanistically, OTUB1 promoted cytokine production in DCs by downregulating K48-linked ubiquitination and increasing the stability of UBC13, an E2-conjugating enzyme critical for the activation of canonical NF-κB and MAPK signaling."
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"Since K48-linked ubiquitination is associated with protein degradation, OTUB1 increases the stability of UBC13."
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"Interestingly, OTUB1 is not involved in the cleavage of polyubiquitin chains but directly targets UBC13 [77]."
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