IndraLab

Statements


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"Betulinic acid suppresses constitutive c-Src, JAK1 and JAK2 activation."

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"Pandey et al. [195] found that betulinic acid inhibited constitutive activation of STAT3, Src kinase, JAK1, and JAK2."

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"We found that betulinic acid inhibited constitutive activation of STAT3, Src kinase, JAK1 and JAK2."

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"Several plant groups have been studied, including phenols (including resveratrol, curcumin, bergamottin, capillarisin, emodin, garcinol, cardamonin, casticin, and apigenin that inhibit JAK1,2 as well as STAT3), steroids (including diosgenin, ergosterol peroxide, and guggulsterone that inhibit JAK1/JAK2 and DNA binding activity as well as STAT3), and terpenoids (including cucurbitacin, andrographolide, betulinic acid, cryptotanshinone, celastrol, oridonin, and alantolactone that inhibit JAK1 and JAK2 as well as STAT3 and STAT5) and these studies have yielded promising results for cancer prevention and therapy [ xref ]."

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"Betulinic acid inhibited the constitutive activation of STAT3, Src kinase, JAK1, and JAK2."