IndraLab

Statements

sparser
"A. thaliana OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
sparser
"Interestingly, there is a novel oxyanion hole inside OTUB2 generated by the active site loop, which may be conducive to the interaction between OTUB2 and ubiquitin ( xref )."
35309903
sparser
"The deleterious effect of NEM on OTU2 UB chain binding indicates that other Cys residues are likely critical."
24659992
sparser
"Among the eleven A. thaliana OTU DUBs examined, we found that OTU2 and OTLD1 bind UB chains with distinct linkage preferences."
24659992
reach
"Structure of human OTUB2 bound to Ub."
25590432
reach
"Since OTUB2 does not have the N-terminal helix and its alpha1alpha2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432
sparser
"LotA OTU2 binds to positively charged ubiquitin residues (R42, R72, R74) through the acidic patch (D407, D410, D412) on the EHL."
35651329
sparser
"Although the local resolution was lower due to flexibility (4.0–7.0 Å), we observed a clear density for ubiquitin bound to the Otu2 S1 site (Supplementary Figs.  xref , xref , and xref , xref )."
37169754
sparser
"Like in other Ub-binding proteins and OTU domain containing proteins, Otu2 binds to ubiquitin via a conserved hydrophobic region in the S1 site of the OTU domain (Tyr223, Phe225, Leu255) recognizing a corresponding hydrophobic patch in ubiquitin (Leu8, Ile44, Val70), as described before for various types of ubiquitin-binding proteins including the OTU family of DUBs xref , xref , xref – xref (Fig.  xref )."
37169754
sparser
"Structure of human OTUB2 bound to Ub."
25590432
sparser
"Since OTUB2 does not have the N-terminal helix and its α1α2 loop is 2 residues shorter, it is expected that the binding of proximal Ub to OTUB2 is substantially different from OTUB1."
25590432