IndraLab

Statements


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"The Zn significantly down-regulated the TLR4, MYD88, NF-κB p65 and p-NF-κB p65 proteins in jejunum treated with DSS (P < 0.05)."

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"Zn inhibits IkappaB kinase (IKK) and NF-kappaB downstream of MyD88 that could potentially attenuate a TLR4 response by dephosphorylation of these phosphate dependent kinases."

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"To understand whether Zn inhibited MyD88 or TRIF signaling, or both, we queried whether Zn suppressed the proinflammatory response of DCs to TLR2 and TLR3 ligands."