IndraLab

Statements

Sirolimus inhibits CASP1. 7 / 7
| 7
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"The 45 kD or 20 kD caspase-1 was increased by I/R or CsA, respectively, and decreased by rapamycin (P < 0.05)."
16221205
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"Similarly, rapamycin, a selective mTORC1 inhibitor (Benjamin et al., 2011), suppressed caspase-1 activation in wild-type BMDMs in response to LPS and ATP, compared to vehicle control."
26119735
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"Caspase-1 remained activated in GMs after treatment with rapamycin, although to a lesser extent than with LPS and ATP, while rapamycin inhibited caspase-1 activation in control macrophages."
26486234
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"Rapamycin treatment significantly suppressed IL-1beta secretion and caspase-1 cleavage in a dose dependent manner."
28489580
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"Rapamycin effectively downregulated the mRNA expression levels of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), toll-like receptor 4 (TLR4), nucleotide binding oligomerization domain-like receptors (NLR) family pyrin domain-containing 3 (NLRP3), and Caspase-1, and suppressed the infiltration of neutrophils and macrophages."
37315833
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"Similarly, rapamycin, a selective mTORC1 inhibitor, suppressed caspase-1 activation in wild type BMDM in response to LPS and ATP, compared to vehicle control (XREF_FIG)."
26119735
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"In contrast to the finding with 3-MA, rapamycin inhibited PrP106-126-induced activation of caspase-1 (p45), and microglial cells produced decreased level of caspase-1 p10."
29720937