IndraLab

Statements

USP14 activates glucose. 5 / 5
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"HG-Evoked Activation of NF-kappaB Signaling Was Suppressed by USP14 Knockdown or miR-26a-5p Elevation."
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"The abovementioned findings confirm that silenced USP14 represses HG-mediated activation of NF-κB signaling in Müller cells."
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"Research has shown that USP14 increases the levels and stability of 3′,5′-cyclic adenosine monophosphate response element-binding protein, enhancing the action of glucagon and hepatic glucose production, thereby promoting hyperglycemia (Liu et al., 2019)."
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"Exogenous overexpression of USP14 in the liver significantly increased hepatic glucose output."
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"In DR patients, USP14 can modulate inflammatory response through the TGF-β1 signal transduction, IκBα and NF-κB signaling pathway s in HG-treated Müller cells, as well as reactive oxygen species (ROS) (126)."
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