IndraLab

Statements

KCNA2 binds MTX1. 4 / 4
| 4
sparser
"The principal MTX-Kv1.2 channel interactions derived from the refined structure were analyzed and displayed using the LIGPLOT program ( McDonald and Thornton, 1994; Wallace et al., 1995 ), shown in F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12414674
sparser
"In all, the pairs of interacting residues on MTX and the IK(Ca) channel of the bound complex indicated that electrostatic and Van der Waal interactions contributed equally to the formation of a stable MTX-IK(Ca) complex, in contrast to the MTX-Kv1.2 binding that is dominantly mediated by electrostatic forces."
21262000
sparser
"Despite the unusual disulfide bridge motif, the binding of MTX to Kv1.2 belongs to the first situation, i.e., mainly via its two antiparallel β -sheets, whereas its α -helix is far away from the int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12414674
sparser
"Our triplet analyses of the BD simulations show that Lys27 in MTX interacts with Asp378 in Kv1.2 ( Table 2 )."
12414674