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REST increases the amount of HCN4. 2 / 2
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"By using genetically modified mice that express a dominant negative form of the transcriptional repressor neuron-restrictive silencing factor (dnNRSF-Tg), the authors generated a model of heart failure 11 : NRSF, a regulator of the fetal cardiac gene program, activates the reexpression of HCN2 and HCN4 to induce dilated cardiomyopathy."
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"XREF_BIBR - XREF_BIBR In earlier studies, we showed that a transcriptional repressor, NRSF, negatively regulates the expression of the HCN2 and HCN4 genes and that a transcriptional activator, MEF2, positively regulates HCN4 expression in cardiac myocytes."
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