IndraLab

Statements

Beta1 subunit activates KCNMA1. 10 / 10
| 1 9
reach
"Hence, the inability of the beta1 subunit to increase burst duration of Slo1 core and Slo3 tail channels, even though the beta1 subunit is functionally associated with the channel, suggests that either the Slo1 tail (or some part of the Slo1 tail) is required for the beta1 subunit to have its characteristic effects, or that the Slo3 tail blocks the effects of the beta1 subunit acting at a site separate from the tail."
12451052
reach
"These results indicate that LRRC26 knockdown does not inhibit beta1 subunit mediated BK channel activation."
24906643
reach
"XREF_BIBR, XREF_BIBR Our data obtained using lithocholate, show that LRRC26 knockdown did not inhibit beta1 subunit mediated BK channel activation."
24906643
reach
"The latter implies that beta1 subunit expression induces BK channel current inhibition by ethanol at intracellular Ca 2+ levels similar to those reached during cerebral myocyte contraction (4-30 muM)."
25346693
reach
"For example, the beta1 subunit appears to mediate the regulation of maxi-K + channels by estrogens and increases the sensitivity of the alpha-subunit to Ca 2+."
15955878
eidos
"In the current study , we have for the first time provided evidence that chronic administration of tacrolimus , a potent and commonly prescribed immunosuppressive drug , may inhibit BK channels , particularly by down-regulating their beta1 subunit expression and functions , in vascular SMCs , leading to enhanced vasoconstriction and ultimately hypertension ; accordingly , the administration of BK channel openers should be a promising option during the clinical use of tacrolimus to prevent this immunosuppressive drug from inducing hypertension ."
33033891
reach
"We conclude that the lower expression of the beta1 subunit during genetic borderline and severe hypertension reduced BK channel activity by decreasing the sensitivity of these channels to physiological changes in Ca2+."
14551242
reach
"Beta1 subunit increases the apparent Ca 2+ / voltage sensitivity of BK channel, and affects the contractility of the vascular smooth muscle cells."
29545539
reach
"This study further examines the mechanism by which the beta1 subunit modulates the gating of the BK channel by exploring which structure features of the alpha subunit are involved in the dual action of the beta1 subunit, of increasing the apparent Ca 2+ sensitivity and decreasing the voltage sensitivity."
12451052
reach
"Several studies have demonstrated that beta1 subunit induced modification of BK channel gating at physiological conditions of voltage and Ca 2+ i translates into an increased basal BK NP o [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
28012000