IndraLab

Statements

KCNH2 inhibits cell cycle. 4 / 4
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"It is noteworthy that the hERG blocker erythromycin blocks cell cycle in G2 phase if administered together with vincristine."
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"11 It has also been shown that constitutive inhibition of the hERG1 channel activity can induce cell cycle arrest in G0/G1 phase in several cancer cells."
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"Reduced expression of the hERG protein by siRNA transfection resulted in decreased cell proliferation in small cell lung cancer cells [XREF_BIBR], and a hERG channel promoted the proliferation of ovarian cancer cells by affecting the cell cycle [XREF_BIBR]."
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"In many tumor cells, HERG channel inhibitors induce antiproliferative properties by retarding the cell cycle progression through a partial block of the cells in the G1 phase of the cell cycle [15,16]."
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