IndraLab

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Nigericin inhibits CASP1. 15 / 15
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"Downregulated platelet caspase-1 activity in platelet specific TLR4 knockout mice was significantly reversed by the NLRP3 activator Nigericin, which did not occur in platelets derived from TLR4 Flox controls (XREF_FIG), indicating that activation of platelet NLRP3 is mediated via TLR4."
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"As 2 O 3 and NaAsO 2 inhibited nigericin mediated caspase-1 processing and IL-1beta maturation (XREF_FIG)."
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"To confirm VX765 inhibition of Caspase 1, cells were treated with LPS and Nigericin, which activates NLRP3 to produce the active caspase."
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"Then, flow cytometry, LDH assay and western blotting demonstrated that tCQA could inhibit LPS- and nigericin-induced Caspase-1 activation and gasdermin D cleavage, thereby suppressing inflammatory cell death."
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"Nigericin, known as an agonist of NLRP3 inflammasome-mediated pyroptosis, reversed the effects of eleutheroside E. Eleutheroside E prevented HAHI and inhibited inflammation and pyroptosis via the NLRP3/caspase-1 signalling pathway."
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"POP2 expression reduced nigericin mediated caspase-1 activation from 19.6 to 5.4% of cells, which is only slightly less potent than the 1.4% of cells that we observed in Asc -/- BMDM."
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"Under these conditions , EC144 inhibited LPS and nigericin induced caspase-1 activation with an IC50 of 150 nM ( Figure 1D ) ."
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"The reversibility of nigericin triggered caspase-1 activation in CD66b + CD16 dim granulocytes and CD14 dim CD16 + monocytes of recovered patients reinforced our interest of this value as a biomarker of COVID-19 severity."
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"Although nigericin stimulated caspase-1 activation and activity are only modestly attenuated in caspase-8-deficient (Casp8 (-/-) Rip3 (-/-)) BMDC, these cells do not exhibit the rapid loss of viability of WT cells."
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"In fact, caspase-1 deficiency impaired plasma membrane permeabilization induced by nigericin (XREF_FIG), meanwhile melittin induced plasma membrane permeabilization was independent on caspase-1 (XREF_FIG)."
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"inhibited LPS and nigericin induced caspase-1 activation with an IC 50 of 150 nM ( Figure 1D ) ."
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"TRP blockers are also effective in inhibiting monosodium urate (MSU) crystal- and nigericin induced caspase-1 activation, but the specific involvement of TRP channels, particularly of TRPV2, in NLRP3 activation has still to be confirmed using genetic ablation in mouse models [XREF_BIBR]."
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"Second, HA tagged HSP70 transfected in murine BMDMs triggered a decrease in ATP and nigericin induced caspase-1 activation and IL-1beta maturation, as compared to HA-empty vector transfected cells."
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"Seventy-two hours after iBMDMs were transfected with siRNA, HDAC6 was knocked down (XREF_SUPPLEMENTARY), and iBMDMs exhibited markedly reduced nigericin stimulated caspase-1 activation (XREF_SUPPLEMENTARY), cell death (XREF_SUPPLEMENTARY), and IL-1beta secretion (XREF_SUPPLEMENTARY)."
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"Expression of full-length NLRP11 or the LRRs led to a significant reduction of nigericin-induced caspase-1 activation."
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