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Nigericin inhibits CASP1. 16 / 16
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"To confirm VX765 inhibition of Caspase 1, cells were treated with LPS and Nigericin, which activates NLRP3 to produce the active caspase."
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"POP2 expression reduced nigericin mediated caspase-1 activation from 19.6 to 5.4% of cells, which is only slightly less potent than the 1.4% of cells that we observed in Asc -/- BMDM."
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"We found that caspase-1 activity was significantly inhibited by preincubation with the GBE both in LPS and nigericin, as well as in cells treated only with nigericin (p < 0.0001; Figure 4a,b)."
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"51 We examined the effect of ENB on NLRP3 inflammasome activation in BLaER1 cells and found that ENB did not inhibit nigericin-induced caspase-1 cleavage and IL-1β release, confirming that ENB inhibits NLRP3 inflammasome activation by targeting NEK7 (Figures 3H and 3I)."
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"In fact, caspase-1 deficiency impaired plasma membrane permeabilization induced by nigericin (XREF_FIG), meanwhile melittin induced plasma membrane permeabilization was independent on caspase-1 (XREF_FIG)."
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"As a substrate of active caspase-1, the full length GSDMD (GSDMD-FL) was cleaved to produce its N-terminal fragment (GSDMD-NT, 32 kDa), and DMF also inhibited the generation of GSDMD-NT in BMDMs treat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"No effects on potassium efflux, chloride efflux, mitochondrial damage or mitochondrial ROS production were detected.CY-09 reduced nigericin-triggered caspase-1 activation and IL-1β secretion both in h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Second, HA tagged HSP70 transfected in murine BMDMs triggered a decrease in ATP and nigericin induced caspase-1 activation and IL-1beta maturation, as compared to HA-empty vector transfected cells."
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"Although nigericin stimulated caspase-1 activation and activity are only modestly attenuated in caspase-8-deficient (Casp8 (-/-) Rip3 (-/-)) BMDC, these cells do not exhibit the rapid loss of viability of WT cells."
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"TRP blockers are also effective in inhibiting monosodium urate (MSU) crystal- and nigericin induced caspase-1 activation, but the specific involvement of TRP channels, particularly of TRPV2, in NLRP3 activation has still to be confirmed using genetic ablation in mouse models [XREF_BIBR]."
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"As 2 O 3 and NaAsO 2 inhibited nigericin mediated caspase-1 processing and IL-1beta maturation (XREF_FIG)."
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"Downregulated platelet caspase-1 activity in platelet specific TLR4 knockout mice was significantly reversed by the NLRP3 activator Nigericin, which did not occur in platelets derived from TLR4 Flox controls (XREF_FIG), indicating that activation of platelet NLRP3 is mediated via TLR4."
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"Seventy-two hours after iBMDMs were transfected with siRNA, HDAC6 was knocked down (XREF_SUPPLEMENTARY), and iBMDMs exhibited markedly reduced nigericin stimulated caspase-1 activation (XREF_SUPPLEMENTARY), cell death (XREF_SUPPLEMENTARY), and IL-1beta secretion (XREF_SUPPLEMENTARY)."
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"Nigericin-mediated caspase-1 activation was also reduced in NLRP11 transfected human macrophages compared to Ctrl transfected cells (Fig. 2c), whereas nigericin-mediated caspase-1 activation was enhanced in NLRP11 cells compared to Ctrl cells (Fig. 2d)."
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"The reversibility of nigericin triggered caspase-1 activation in CD66b + CD16 dim granulocytes and CD14 dim CD16 + monocytes of recovered patients reinforced our interest of this value as a biomarker of COVID-19 severity."
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"Interestingly, nigericin-induced caspase-1 activation and IL-1β release could be obviously blocked by 5,7-dichloro-8-hydroxyquinoline (3) and 8-hydroxyqinaldine (4) (Fig. 5c)."
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