IndraLab
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USP4 activates cell population proliferation. 21 / 21
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"Moreover, USP4 elevation antagonized the OGD/R-induced microglia proliferation and activation by suppressing the NO levels and the expression of the microglial marker IBA-1."
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"Moreover, knockdown of USP4 could significantly inhibit cell proliferation and increase cell apoptosis in U87 and T98G cells."
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"As shown in XREF_FIG, the inhibition of cell proliferation that was induced by USP4 overexpression was markedly reversed following PDCD4 knockdown using siRNA."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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"Depletion of USP15 and USP4 decreased cell proliferation in both H157 (Fig. 1C and Supplementary Fig. 1C, D) and A549 (Supplementary Fig. 1E)."
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"To test this hypothesis, CCK-8 assays were used to investigate the effects of CypA on USP4 induced proliferation of HCC cell lines."
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"In addition , USP4 reportedly mediates cell proliferation , survival and metastasis ( 32 , 33 ) ."
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"Inversely, overexpression of USP4 or CypA in Huh7 and PLC/PRF/5 cells significantly promoted cell proliferation; however, CypA knockdown impaired the effect in Huh7-USP4 and PLC/PRF/5-USP 4 cells."
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"In vitro study showed that knockdown of USP4 inhibited PC cells proliferation, migration and invasion."
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"USP4 and S1P1 were up-regulated in mesenchymal-type liver-tumor cells with miR-148a dysregulation, facilitating migration and proliferation of tumor cells."
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"Taken together, CypA is indispensable for USP4 mediated cell proliferation in HCC."
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"XREF_BIBR also demonstrated that inhibiting USP4 expression in GBM cells both inhibited their proliferation and induced apoptosis via antagonizing USP4 mediated stimulation of the ERK signaling pathway."
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"By promoting activation of the relaxin and TGF-beta 1/Smad2/matrix metalloproteinase 9 axis and transcriptional repression activity of HDAC2, USP4 induces breast cell invasion, migration, and proliferation both in vitro and in vivo."
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"USP15 and USP4 induces cancer cell proliferation via regulating alternative splicing of SRSF1."
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"In summary, these data indicate that USP4 enhances HCC cell proliferation, migration, and invasion and suppresses HCC cell apoptosis in vitro."
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"Similarly, silencing of USP4 also reduced proliferation of MCF7 while overexpression of HDAC2 in cells with USP4 silencing rescued this phenotype (Fig. 6b)."
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"TbetaRI stabilized downstream from TGF-beta signaling causes the phosphorylation of Smad2 and 3, the transcription factors responsible for target gene induction [XREF_BIBR], as verified by our result that USP4 fortified Smad2 phosphorylation and promoted migration and proliferation of hepatoma cell."
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"The inhibition of USP4 in vitro significantly enhanced breast cancer cell growth and proliferation, while the overexpression of USP4 inhibited cell growth and proliferation."
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"The results showed that proliferation was significantly inhibited by USP4 knockdown in MHCC97H and LM3 cells (P < 0.01), and was rescued by co-transfection with a shRNA resistant USP4 cDNA (P < 0.01)."