IndraLab

Statements

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"USP4 and S1P1 were up-regulated in mesenchymal-type liver-tumor cells with miR-148a dysregulation, facilitating migration and proliferation of tumor cells."
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"Notably, this study demonstrated that USP4 promotes PTC proliferation by modulating the MAPK and AKT signaling pathways."
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"In summary, these data indicate that USP4 enhances HCC cell proliferation, migration, and invasion and suppresses HCC cell apoptosis in vitro."
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"TbetaRI stabilized downstream from TGF-beta signaling causes the phosphorylation of Smad2 and 3, the transcription factors responsible for target gene induction [XREF_BIBR], as verified by our result that USP4 fortified Smad2 phosphorylation and promoted migration and proliferation of hepatoma cell."
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"As shown in XREF_FIG, the inhibition of cell proliferation that was induced by USP4 overexpression was markedly reversed following PDCD4 knockdown using siRNA."
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"By promoting activation of the relaxin and TGF-beta 1/Smad2/matrix metalloproteinase 9 axis and transcriptional repression activity of HDAC2, USP4 induces breast cell invasion, migration, and proliferation both in vitro and in vivo."
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"XREF_BIBR also demonstrated that inhibiting USP4 expression in GBM cells both inhibited their proliferation and induced apoptosis via antagonizing USP4 mediated stimulation of the ERK signaling pathway."
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"The inhibition of USP4 in vitro significantly enhanced breast cancer cell growth and proliferation, while the overexpression of USP4 inhibited cell growth and proliferation."
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"In addition , USP4 reportedly mediates cell proliferation , survival and metastasis ( 32 , 33 ) ."
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"METTL3 elevates the levels of oncogenes such as THRAP3, RBM25, USP4, and BZW2, which accelerate the proliferation of MM cells and inhibit apoptosis [233, 234]."
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"To test this hypothesis, CCK-8 assays were used to investigate the effects of CypA on USP4 induced proliferation of HCC cell lines."
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"Moreover, USP4 upregulation contributes to enhanced proliferation in MM cells [22]."
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"USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1."
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"USP4 promotes proliferation and metastasis in human lung adenocarcinoma."
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"Loss- and gain-of-function assays suggested that USP4 silencing inhibited ESCC cell proliferation, migration, and invasion, while USP4 overexpression promoted these behaviors."
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"USP4 can target the TGF-β receptor for deubiquitination and enhance the activation of the TGF-β/BMP signaling pathway to promote the proliferation and differentiation of MSCs (69)."
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"Importantly, USP4 promotes ESCC proliferation, migration, and invasion via the MEK/ERK signaling pathway and can be inhibited by U0126."
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"Similarly, silencing of USP4 also reduced proliferation of MCF7 while overexpression of HDAC2 in cells with USP4 silencing rescued this phenotype (Fig. 6b)."
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"USP4 induces ESCC cell proliferation and tumor growth."
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"In addition, USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1."
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"Colony formation assays demonstrated that shUSP4#2 and shUSP4#3 significantly inhibited the proliferation of KYSE150 cells (Fig. 2C) and that USP4 overexpression significantly promoted the proliferation of KYSE180 cells (Fig. 2D)."
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"Usp4 deletion significantly decreases protein synthesis, proliferation and reconstitution capacity of HSCs."
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"Together, these findings indicate that USP4 promotes cell proliferation and tumor growth in ESCC."
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"USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2."
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"Inversely, overexpression of USP4 or CypA in Huh7 and PLC/PRF/5 cells significantly promoted cell proliferation; however, CypA knockdown impaired the effect in Huh7-USP4 and PLC/PRF/5-USP 4 cells."
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"Moreover, USP4 elevation antagonized the OGD/R-induced microglia proliferation and activation by suppressing the NO levels and the expression of the microglial marker IBA-1."
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"Therefore, we guessed that USP4 could promote cell proliferation and inhibit apoptosis."
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"Overexpression of USP4 promotes cell proliferation, glucose uptake, and lactate production in gastric cancer cells."
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"SPSS statistical analysis showed that silencing USP4 expression inhibited the proliferation of lung adenocarcinoma cells, and the difference was statistically significant P < 0.05(Fig. 3C)."
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"Depletion of USP15 and USP4 decreased cell proliferation in both H157 (Fig. 1C and Supplementary Fig. 1C, D) and A549 (Supplementary Fig. 1E)."
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"Usp4 inhibition suppresses ribosome biogenesis and proliferation of leukemic cells, and prolongs the survival of AML (Acute myeloid leukemia) mice."
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"Conversely, the function of USP4 in promoting the proliferation, migration, and invasion abilities of KYSE180 cells was largely reversed by the knockdown of TAK1 (Supplementary Fig. 2A-C)."
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"Taken together, CypA is indispensable for USP4 mediated cell proliferation in HCC."
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"USP4 accelerates HCC cell proliferation, migration, and invasion in vitro."
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"USP4 promotes gastric cancer cell proliferation."
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"As shown in Fig 3A, USP4 dramatically increased the proliferation of AGS cells."
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"Third, USP4 increased cell proliferation and enhanced the Warburg effect through its regulation of PKM2.Recent studies found that USP4 is often overexpressed in various cancers, such as glioblastoma [23], liver cancer [24, 25], colorectal cancer [26, 27], and melanoma [28], but its role in gastric cancer is unknown."
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"USP15 and USP4 promote cell proliferation and invasion in lung cancer cell lines."
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"In agreement with this, depletion of USP4 in AGS cells (Fig 2C) obviously reduced cell proliferation (Fig 3B)."
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"This result clearly indicates that PKM2 is a mediator for USP4 function in gastric cancer cells.Similarly, the colony formation assay results (Fig 3D–3F) indicated that USP4 promotes gastric cancer proliferation by regulating PKM2."
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"Deubiquitination enzyme USP15 and its similar parallel gene USP4 were overexpressed and promoted the proliferation of lung cancer cells by regulating SRSF1 alternative splicing (67)."
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"The results showed that proliferation was significantly inhibited by USP4 knockdown in MHCC97H and LM3 cells (P < 0.01), and was rescued by co-transfection with a shRNA resistant USP4 cDNA (P < 0.01)."
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"In contrast, depletion of USP4 significantly inhibited proliferation, migration, and invasion abilities in vitro and suppressed tumor growth and metastasis in vivo."
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"USP4 established its tumor-promoting function (enhancing cell proliferation and the Warburg effect) in gastric cancer cells by upregulating PKM2."
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"USP15 and USP4 induces cancer cell proliferation via regulating alternative splicing of SRSF1."
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"The results of tumorigenesis experiment in nude mice showed that USP4 could promote tumor proliferation and promote tumor in vivo.In summary, we found that USP4 is highly expressed in lung adenocarcinoma."
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"USP4 regulates the cell cycle and apoptosis and promotes tumor cell proliferation by regulating the p53 and downstream protein expression."
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"On the other hand, SRSF1 is upregulated by high USP15 and USP4 that enhance cell proliferation and invasion (Fig. 7D)."
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