IndraLab

Statements

TNFAIP3 inhibits IL17A. 5 / 5
| 4 1
eidos
"A20 can block IL-17 production and IL-17-mediated inflammatory aggravation during anti-TNF treatment by preventing the prolonged phosphorylation of JNK and inhibiting p38 MARK and PKC activity , which is dependent on the ZnF7 motif of A20 ."
| PMC
eidos
"Recently , we demonstrated that the prevention of TNFalpha signaling in conventional CD4 + memory T cells leads to inhibition of TNFAIP3 / A20 expression , which subsequently leads to enhanced IL-17A expression ( 20 ) ."
32038615
eidos
"A20 can block IL-17 production by interrupting the MAPK signaling pathway through abrogating K63 ubiquitination of TNF receptor associated factor 6 ( TRAF6 ) and preventing the prolonged phosphorylation of c-Jun-N-terminal-kinase ( JNK ) , which are both important for MAPK activation [ 46 ] ."
| PMC
sparser
"Using RNA-silencing and A20 −/− cells, we showed that the expression of various IL-17 target genes was inhibited by A20 ( xref to xref )."
23737552
eidos
"Both ABIN1 and A20 appear to independently inhibit IL-17 signaling ."
30543901