IndraLab

Statements

Hypoxia activates USP28. 2 / 2
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eidos
"Our data display that hypoxia modulates the activity of USP28 , which leads to the question whether hypoxia also regulates USP28 SUMOylation ."
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eidos
"Results Here , we report that USP28 is a SUMOylated protein in normoxia with moderate deubiquitinating activity towards HIF-1alpha in vitro , while hypoxia and HIF-1alpha activate USP28 through SENP1-mediated USP28 deSUMOylation to further accumulate HIF-1alpha protein in cells ."
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