IndraLab

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ATXN3 activates ATM. 3 / 3
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"We also found that ATXN3 and eukaryotic translation initiation factor 5A2 (EIF5A2) protein levels in ATC tissues are positively correlated, and ATXN3 promotes the proliferation and metastasis of ATC cells through EIF5A2."
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"Since oxidative stress alone can activate the ATM pathway [ xref ], we sought to determine whether mutant ATXN3 activates ATM via an oxidation-dependent mechanism."
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"Moreover, various gain/loss functional assays were performed to indicate that ATXN3 overexpression enhanced ATC cell proliferation and metastasis."
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