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ATXN3 activates ATM. 4 / 4
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"Moreover, our results indicated that ATXN3 promotes ATC proliferation and metastasis in vitro."
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"In addition, the protein level of EIF5A2 was also significantly consistent with the protein level of ATXN3 in clinical ATC tissues, while the mRNA expression level of ATXN3 was not consistent with the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Since oxidative stress alone can activate the ATM pathway [ xref ], we sought to determine whether mutant ATXN3 activates ATM via an oxidation-dependent mechanism."
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"Then, we demonstrated that ATXN3 can promote the proliferation and metastasis of ATC cells in vivo and in vitro."
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