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OTUB2 activates Neoplasms. 10 / 10
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"When cultured in suspension, OTUB2 deficiency sharply reduced the number of tumor-like mammospheres, whereas ectopic expression of OTUB2-wild-type (OTUBS-WT), but not of the CS mutant, greatly enhance[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Statistical analysis confirmed that loss of OTUB2 decreased the frequency of tumor-initiating cells ( Table S3 )."
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"Zhang et al. [12] demonstrated that OTUB2 promoted tumor metastasis by independently activating YAP and TAZ."
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"These results suggest that when the expression of OTUB2 in ESCC cell line KYSE150 was down regulated, the proliferation, migration and invasion of KYSE150 cells is inhibited, which further indicates that OTUB2 knockdown can inhibit the growth and progression of tumor."
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"These authors found that OTUB2 could directly act on YAP1/TAZ independently of the Hippo signaling pathway to promote tumor proliferation."
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"OTUB2 promotes TNBC cell proliferation in vitro and tumor growth."
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"The subcutaneous xenograft model showed that OTUB2 knockdown suppressed tumor growth in vivo (Fig. 3E–G)."
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"In ESCC, DNA hypermethylation of otubain 2 (OTUB2) has been found to induce tumor initiation and chemoresistance by regulating biosynthesis of phosphatidylserine."
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"Furthermore, in vivo assays show that knockout of OTUB2 inhibits tumor growth in mice."
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"OTUB2-WT expression increased spontaneous lung metastasis without affecting primary tumor growth, whereas expression of OTUB2-CS or OTUB2-KR had no significant effects ( Figure 5 E–5H)."
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