IndraLab

Statements

USP13 binds AMFR. 18 / 19
3 | 4 11
sparser
"It appears that the second UBA domain is crucial for USP13 to bind gp78."
24424410
sparser
"The requirement of gp78 interaction for ERAD inhibition by ectopic USP13 indicates that the interaction of USP13 with gp78 is functionally relevant to ERAD."
24424410
biogrid
No evidence text available
24424410
biogrid
No evidence text available
24424410
biogrid
No evidence text available
24424410
sparser
"Importantly, USP13 associates with AMFR to prevent polyubiquitylation of UBL4A, protecting the BAG6 complex from proteasomal degradation and maintaining proper ERAD pathway function [ xref ]."
32311336
sparser
"Thus, the association of USP13 with AMFR prevents collateral damage in the ERAD pathway by promoting the distinction between bona fide ERAD substrates and protein complexes that ERAD pathway E3s must engage to ensure proper substrate shuttling for degradation."
32311336
sparser
"Interestingly, USP13 associates with gp78 to attenuate polyubiquitination of ubiquitin-like protein 4A (UBL4A), a part of the Bag6 complex that helps chaperone retrotranslocated ERAD substrates to the proteasome, thereby protecting the Bag6 complex from proteasomal degradation and maintaining an adequate ERAD pathway, highlighting the importance of the associated DUB activity during ERAD [ xref ]."
33669844
sparser
"Recently, cleaved Bag6 induced by caspase three activation was reported to interact with LC3-Ⅰ and pro-LC3 under ER stress conditions such as gp78 overexpression and USP13 downregulation, leading to autophagy inhibition and apoptosis activation ( xref )."
36188217
reach
"USP13 interacts directly with gp78 in ERAD."
24424410
reach
"Several lines of evidence confirmed that gp78 could bind to USP13 directly and promote its interaction with p97."
24424410
sparser
"Our study reveals an unexpected interaction between USP13 and the ERAD-specific ubiquitin ligase gp78."
24424410
reach
"An endogenous interaction between USP13 and gp78 was also detected (XREF_FIG)."
24424410
reach
"These results demonstrated a specific and direct interaction between USP13 and gp78 that facilitates USP13-p97 association."
24424410
sparser
"This result is consistent with our model that ERAD inhibition by USP13 overexpression is probably achieved by blocking functional protein–protein interactions required for ERAD through the binding of USP13 with gp78."
24424410
sparser
"USP13 interacts directly with gp78 in ERAD."
24424410
sparser
"Several lines of evidence confirmed that gp78 could bind to USP13 directly and promote its interaction with p97."
24424410
sparser
"An endogenous interaction between USP13 and gp78 was also detected ( xref )."
24424410