IndraLab

Statements

TNF inhibits KCNH2. 5 / 6
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"Furthermore, studies conducted in animal models have shown that inflammatory markers, specifically TNF-α, can diminish the hERG current in HEK 293 cells expressing hERG in a concentration-dependent manner."
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"TNF-alpha consistently and reversibly decreased HERG current (I (HERG))."
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"Wang et al. previously demonstrated that TNF-alpha decreased hERG current density in HEK293 cells, significantly depressed I Kr density and prolonged APD in canine ventricular myocytes, primarily due to changes in reactive oxygen species (ROS)."
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"Tumor necrosis factor-alpha (TNF-alpha), a critical factor causing heart failure and when overexpressed prolonging APD and promoting ventricular arrhythmias, suppresses HERG function XREF_BIBR."
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"In addition, TNFα downregulates the rapid component of the delayed rectifier potassium current (IKr) by impairing human ether-a-go-go-related gene (hERG) potassium channel function (34), while IL-6 and IL-1 also prolong action potential duration (APD) by enhancing the L-type calcium current (ICaL) (35, 36)."
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