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PPP2 leads to the dephosphorylation of HCN4 on tyrosine. 2 / 2
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"PP2 at 10muM can nearly abolish the tyrosine phosphorylation of HCN4 after 30min incubation."

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"In this work, we showed that PP2 significantly reduced tyrosine phosphorylation of HCN4 in isolated sinus node myocytes (4B, green, compared to 4A, green)."