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Inosine inhibits IRF3. 2 / 2

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"In addition, recent studies showed that inosine containing dsRNAs can inhibit activation of IRF3 and therefore the downstream interferon signaling pathway, possibly by functioning as competitive inhibitors of RIG-I and MDA5 [17]."

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"Similarly , inosine suppressed TBK1 , IRF3 , and NF-kappaB phosphorylation promoted by LPS , SARS-CoV-2 , or Poly ( I :C ) infection ( Figs ."

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Inosine inhibits IRF3. 2 / 2

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