IndraLab

Statements

USP5 increases the amount of TP53. 6 / 6
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"Additionally, USP5 knockdown increased levels of p53 but not MDM2, increased p53 activity and increased transcription of p53 target genes."
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"We used Usp5 knockdown (KD), overexpression and enzyme inhibition to demonstrate that Usp5 suppresses p53 and FAS levels in melanoma and is associated with loss of checkpoint control and apoptotic sensitivity to kinase inhibitors and other agents."
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"On the other hand, ablation of USP5 or BECN1 significantly upregulated p53 expression to induce cellular senescence and inhibit KRAS -induced cell growth (Fig. 6a–f)."
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"This premise is corroborated by the observations that Beclin 1 , which is unable to promote autophagy, can rescue USP5 ablation-induced upregulation of p53 expression and senescence."
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"Through inhibition of USP5, p53 and rescue experiments, it was shown that USP5 activates the transcription of p53 by causing DNA damage, thereby causing an increase in apoptosis, autophagy and cycle arrest."
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"However, both Beclin 1 and Beclin 1 were able to rescue the expression levels of p53 and p21 induced by USP5 ablation, resulting in suppression of USP5 ablation-induced cellular senescence and cell growth inhibition (Fig. 4j–l)."
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