IndraLab

Statements

BAP1 increases the amount of EZH2. 3 / 3
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"In mouse models, the loss of BAP1 leads to elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) expression and enhanced repression of polycomb repressive complex 2 (PRC2) targets [48]."
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"2 BAP1 inactivation increases expression of enhancer of zeste homolog 2 (EZH2) or histone-lysine N-methyltransferase EZH2, 3 a component of the histone methyltransferase Polycomb repressive complex 2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tazemetostat, a BAP1 inhibitor, increases the level of the PCR2 complex protein EZH2, activated by BAP1, and might be a potential drug for rhabdoid meningioma caused by BAP1 loss (NCT02860286) (50)."
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