IndraLab

Statements

Chrysophanol inhibits NLRP3. 5 / 5
| 5
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"Zhang et al. (2014) reported that chrysophanol suppressed NALP3 inflammasome activation (which consists of NALP3, ASC, and caspase‐1) for occlusion of the median cerebral artery (MCAO) and reperfusion (Zhang et al. 2014)."
36648526
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"Immunoglobulin treatment, intermittent fasting, and intraperitoneal injection of the fungal isolate chrysophanol, all attenuate NLRP3 inflammasome activity and have been shown to reduce ischemic brain damage [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26473731
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"Chrysophanol, the main active ingredient from Dahuang (Radix Et Rhizoma Rhei), Heshouwu (Radix Polygoni Multiflori) and Huzhang (Rhizoma Et Radix Polygoni Cuspidwi), can inhibit the activation of NLRP3 induced by transient MCAO (tMCAO) in mice, but the specific pathway mediated by it is not clear at present, which needs to be further explored (Zhang et al., 2014)."
37153784
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"Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia and Reperfusion in Mice."
24876671
reach
"Chrysophanol could inhibit the activation of NALP3 inflammasome and protect cerebral ischemic stroke."
24876671