IndraLab

Statements


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"UBPY binds components of ESCRT-III [ xref ]."

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"UBPY binds components of ESCRT-III [139] ."

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"The MIT-domain of Usp8 interacts with ESCRT-III proteins and is therefore important for endosomal recruitment which is required for EGFR degradation [27,30] ."

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"For example, USP8’s interaction with ESCRT-III parallels Parkin-mediated mitophagy in PD, while STXBP6’s homology to Munc18-1, a protein mutated in early-onset PD, suggests evolutionary conservation of synaptic maintenance mechanisms [ xref ]."